intimal hyperplasia (IH) that develops in the midterm period (3-24 mo) of graft maturation. ... may be broken into three phases, during which failure may occur: (1) early, within 30 d of implantation, (2) midterm, after 3-24 mo, and(3)long-term, aftermore than 2 …
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Intimal hyperplasia, atherosclerosis, and rupture of plaques formed in the vein grafts result in an overall patency of 60% after 10 years 3,7,8 . Risk ...
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Introduction. Intimal hyperplasia (IH) is a buildup of myofibroblast-like cells (neointimal cells) and extracellular matrix (ECM) within the tunica intima, the innermost …
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Intimal hyperplasia (IH) is a known complication of all types of vascular procedures, including arterial bypass, angioplasty, stenting, and endarterectomy. The …
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Distal anastomotic intimal hyperplasia is a biologic entity with active cellular and subcellular events. Its biogenesis appears to be influenced by the hemodynamics of blood flow at the distal anastomosis. KEY WORDS: lntimal hyperplasia; distal anastomotic intimal hyperplasia; histopa- thology and biogenesis of intimal hyperplasia.
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Intimal hyperplasia (IH), characterized by the accumulation of smooth muscle cells (SMCs) and extracellular matrix (ECM) in the intima of the vein graft, is the most common cause of limited patency. ... The original wound edge is marked with broken line (*P < 0.05 vs. control). (C) Cell proliferation assay of cultured A7r5 SMC.
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Intimal hyperplasia (IH) occurs in a considerable number of cases of blood vessel reconstruction by stenting or balloon angioplasty, venous bypass grafting, and arteriovenous dialysis accesses. It is triggered by endothelial injury during the vascular intervention and leads to vessel restenosis with life-threatening consequences for patients.
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Intimal hyperplasia, lumen uniformity, graft stenosis, and graft perfusion were measured by intravascular ultrasound and angiography. Major cardiac and cerebrovascular events (MACCE; including death, myocardial infarction, stroke, and revascularization) were recorded over a median follow-up of 3 years. Results: Worse lumen uniformity, greater ...
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Background— Enhanced external counterpulsation (EECP) is a circulation assist device that may improve endothelial dysfunction by increasing shear stress. Chronic exposure of vascular endothelial cells and vascular smooth muscle cells to relatively high physiological shear stress has antiproliferative and vasoprotective effects. The present …
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Despite much effort, synthetic small diameter vascular grafts still face limited success due to vascular wall thickening known as intimal hyperplasia (IH). Compliance mismatch between graft and native vessels has been proposed to be one of a key mechanical factors of synthetic vascular grafts that c …
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Definition of intimal hyperplasia. The subject of my analysis is arterial intimal hyperplasia. This term applies to any cells that form a multi-layer compartment internally to the elastic membrane of the arterial wall and express alpha-smooth-muscle actin, permanently or transitionally [6,7].The pathology of coronary disease comprises a …
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Intimal Hyperplasia. The process of intimal hyperplasia is common to various forms of vascular diseases, such as atherosclerosis, restenosis, and transplant vasculopathy. 15,16) In response to vascular injury, the medial smooth muscle cells proliferate and migrate into the intima, where they proliferate and secrete abundant …
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However, normal or "benign" intimal hyperplasia, although microscopically identical to pathology, is a controllable phenotype that rarely compromises blood supply. It is remarkable that each human heart has coronary arteries in which a single-layer endothelium differentiates early in life to form a multi-layer intimal hyperplasia and then ...
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Intimal hyperplasia is a product of vascular smooth muscle cell proliferation, migration through the internal elastic lamina, and deposition of extracellular matrix proteins driven by growth factors in the vasculature. This vascular pathology results in a progressive diminution of the vessel lumen and serves as a site for thrombosis and ...
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Inflammation drives the cascade of intimal hyperplasia 5.After endothelium injury, infiltrated macrophages express numerous cytokines to initiate the proliferation and migration of smooth muscle ...
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Endometrial hyperplasia: Endometrial hyperplasia refers to an abnormally thickened uterine lining, or endometrium.The cell changes caused by endometrial hyperplasia may be benign or precancerous. …
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By definition, intimal hyperplasia is an abnormal accumulation of cells in the vascular tunica intima; the cell number is increased because of proliferation and/or migration of …
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Intimal hyperplasia may be defined as the abnormal migration and proliferation of vascular smooth muscle cells with associated deposition of extracellular connective tissue matrix. The pathology of intimal hyperplasia is reviewed with particular attention to its physiology, pharmacology, cell biology and molecular biology. ...
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Abstract. Intimal hyperplasia (IH) occurs in a considerable number of cases of blood vessel reconstruction by stenting or balloon angioplasty, venous bypass …
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Diffuse intimal hyperplasia and graft irregularity adversely affect the long-term patency of saphenous vein grafts (SVGs) and clinical outcomes of patients undergoing coronary artery bypass grafting (CABG). The VEST trial evaluated the efficacy of external graft support in limiting the development of intimal hyperplasia (IH) at 1 year …
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Intimal hyperplasia is a product of vascular smooth muscle cell proliferation, migration through the internal elastic lamina, and deposition of extracellular matrix proteins driven …
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Intimal hyperplasia and stenosis are often cited as causes of arteriovenous fistula maturation failure, but definitive evidence is lacking. We examined the associations among preexisting venous intimal hyperplasia, fistula venous stenosis after creation, and clinical maturation failure. The Hemodial …
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Intimal hyperplasia, which increases in frequency with age, and IEL dissociation are not specific to GCA. Isolated involvement of the adventitia and/or vasa vasorum is of uncertain diagnostic significance, as discussed below. The diagnosis of GCA may be retained even if the TAB does not show vasculitis lesions.
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Intimal hyperplasia is the leading cause of long-term failure in coronary artery bypass vein grafting, coronary artery stenting, angioplasty, arteriovenous fistula for dialysis, and allograft transplantation. Intimal hyperplasia is a product of vascular smooth muscle cell proliferation, migration th …
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Intimal hyperplasia (IH), a crucial histopathological injury, forms the basis of vascular stenosis and thrombogenesis. In addition, it is common in maladies such as stenosis at the anastomosis of arteriovenous fistula and restenosis after angioplasty. Various cellular and noncellular components play critical parts in the advancement of IH. …
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Postoperative intimal hyperplasia is the major cause of the vein graft occlusion. It is very important to establish an animal model for the start of research. After my vascular surgery residency in Japan, I started my research work on postoperative intimal hyperplasia at the University of Wisconsin- …
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Background: Diffuse intimal hyperplasia and graft irregularity adversely affect the long-term patency of saphenous vein grafts (SVGs) and clinical outcomes of patients undergoing coronary artery bypass grafting (CABG). The VEST trial evaluated the efficacy of external graft support in limiting the development of intimal hyperplasia (IH) at 1 year postsurgery.
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Fibromuscular dysplasia is a condition that causes the medium-sized arteries in the body to narrow and grow larger. Narrowed arteries can reduce blood flow and affect how body organs work.
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Intimal hyperplasia is a highly complex process that involves several tissues (perivascular, 42 vessel wall, and blood), numerous cell lineages, and multiple molecular signaling networks. Although much has been learned in the past few decades, many mechanistic details remain to be fully elucidated.
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Intimal hyperplasia (IH) is a leading cause of obstruction of vascular interventions, including arterial stents, bypass grafts and arteriovenous grafts and fistulae. Proposals to account for arterial stent-associated IH include wall damage, low wall shear stress (WSS), disturbed flow and, although n …
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